Antidepressant

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Venlafaxine Hydrochloride

Product Name:Venlafaxine Hydrochloride
CAS Registry Number: 99300-78-4
Molecular Formula:C17H28ClNO2
Molecular Weight: 313.86
Purity : 99.0%
Grade: Pharmaceutical Grade
Appearance:White Crystalline Powder
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Description

Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.This means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the body and the brain.


A comparative meta-analysis of 12 major antidepressants found that venlafaxine, mirtazapine, escitalopram, and sertraline were significantly more efficacious than duloxetine, fluoxetine, fluvoxamine, paroxetine, and reboxetine.A combination of venlafaxine and mirtazapine achieved remission rates (defined as a HAM-D score of 7 or less) of 58% in one controlled trial.In combination with an antipsychotic medicine aripiprazole, better results in treatment resistant depression in older adults have been demonstrated.


Venlafaxine is used primarily for the treatment of depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms.At low doses (<150 mg/day), it acts only on serotonergic transmission. At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission.


Due to its action on both the serotoninergic and adrenergic systems, venlafaxine is also used as a treatment to reduce episodes of cataplexy, a form of muscle weakness, in patients with the sleep disorder narcolepsy.Some open-label and three double-blind studies have suggested the efficacy of venlafaxine in the treatment of attention deficit-hyperactivity disorder (ADHD).Clinical trials have found possible efficacy in those with post-traumatic stress disorder (PTSD).


Description

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