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Product Name: PRL-8-53
CAS: 51352-87-5
MF: C18H22ClNO2
MW: 319.8258
Purity: 99%
BP: 398.9°C at 760 mmHg
FP: 134°C
Grade: Pharmaceutical Grade
Appearance: White Powder


PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.

Memory Enhancement

The older subjects in the only human study on PRL-8-53 demonstrated significant improvements in memory after taking a single 5 mg dose. The double-blind study used word memorization as a measure, testing the participants' ability to recall a list of 12 one-syllable words, first to establish a baseline and then again after ingesting PRL-8-53 or a placebo. The subjects were tested on their ability to recall the words 24 hours after hearing them and then again one week later.

The study results indicate that participants who had higher baseline scores showed the least improvement after ingesting PRL-8-53, while subjects who had demonstrated poorer initial memory or who were over 30 years of age showed significant improvement in recall.

Many individual nootropic users who have tried PRL-8-53 confirm its memory-boosting effects, in some cases comparing it to a more powerful version of other nootropics such as nefiracetam and Noopept.


Due to the limited understanding of PRL-8-53's mechanism of action, it may be advised to avoid stacking it with other nootropics.


More evidence is needed to determine the ideal dosage for PRL-8-53. The effective dosage may vary, since the only human study on PRL-8-53 used a single dose of 5mg, while patent information on PRL-8-53 suggests a dosage range of 0.01-4mg/kg, with an 'ideal' range of 0.05-1.2mg/kg.

Side Effects

No adverse effects from a single 5 mg dose of PRL-8-53 were observed in the human study. Animal studies suggest that the compound has a high therapeutic threshold, but the evidence is very limited because no comprehensive toxicity studies have been completed.

Keep in mind, this is a highly experimental research chemical, therefore caution is advised.


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