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Fexofenadine hydrochloride

Product Name: Fexofenadine hydrochloride;
CAS: 153439-40-8;
MF: C32H40ClNO4;
MW: 538.12;
Melting point: 148-150°C;
storage temp.: −20°C;
Apperance:white powder


Fexofenadine hydrochloride Description:

Fexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of selectively peripheral H1 blocker.

 Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors, thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness.

Fexofenadine hydrochloride edical Usage:

Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.

Fexofenadine is used for relief from physical symptoms associated with seasonal allergic rhinitis and for treatment of chronic urticaria. It does not cure but rather prevents the aggravation of allergic rhinitis and chronic idiopathic urticaria and reduces the severity of the symptoms associated with those conditions, providing relief from repeated sneezing, runny nose, itchy eyes or skin, and general body fatigue.

How does fexofenadine work?

Fexofenadine hydrochloride is a type of medicine called a non-sedating antihistamine. It works by preventing the actions of histamine - a substance produced by the body when it reacts to a foreign substance such as pollen or pet fur (an allergen). Histamine acts on histamine receptors, causing a chain reaction that results in allergic symptoms.

In allergic reactions like hay fever, histamine causes inflammation of the nose, eyes or airways, resulting in itchy, watery eyes, a runny, blocked or itchy nose and sneezing. In allergic skin reactions histamine causes skin inflammation, rashes and itching.

Fexofenadine blocks histamine receptors and so stops the chain reaction that causes the symptoms of the allergy. It usually starts to work within half an hour to an hour after taking a dose.

Fexofenadine also helps relieve a type of itchy skin rash called chronic idiopathic urticaria. This is similar to the nettle-type rash or hives that you can get with an allergic reaction, but has no apparent cause. Blocking the actions of histamine relieves the itching and reduces the rash associated with this condition.


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