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Cyproheptadine Hydrochloride

Product Name: Cyproheptadine Hydrochloride
CAS: 41354-29-4;
MF: C21H22ClN;
MW: 323.86;
EINECS: 213-535-1;
Melting point: 165 °C (dec.)(lit.);
solubility: ethanol: soluble;
Apperance:white powder


Cyproheptadine hydrochloride Description:

Cyproheptadine hydrochloride is a kind of pipecolic antihistamines,it can compete with histamine released from the organization for H1 receptor on effector cells , thereby it can prevent the onset of an allergic reaction, and release histamine-induced spasm and congestion effects, this product has a strong H1 receptor antagonism, its anti-histamine effect is stronger than chlorpheniramine, promethazine . There are mild to moderate anti-serotonin effects and anticholinergic effects. In addition, there is a stimulate appetite effect, and weight gains after a certain time. 

Clinically cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially it has a good effect on cold urticaria ), papular urticaria, angioedema, atopic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, allergic to insect stings and migraine. It has some therapeutic effect on bronchial asthma . It is acceptable for the adjuvant treatment of Cushing's syndrome, acromegaly. In addition,as an appetite enhancer,it is used for neuropathic fear of food. There are reports about acanthosis nigricans treatment, prevention of necrotizing pyoderma.

Cyproheptadine hydrochloride  Mdical Usage:

(1). Cyproheptadine is used to treat allergic reactions (specifically hay fever).[6] It is also used to treat vasomotor mucosal edema, including vasomotor rhinitis and edema of the throat.

(2). It has shown effectiveness in the treatment of nightmares, including those related to post-traumatic stress disorder.

(3). It has been used in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor.

(4) .It can also be used as a preventive measure against migraine in children and adolescents.In Australia this is the only indication for which cyproheptadine is subsidised by the PBS.

(5). It can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).

(6). It is also used in the treatment of cyclical vomiting syndrome;

(7).Use of the drug can stimulate the appetite and may lead to weight gain, which is helpful for underweight people.

(8).According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, and mood and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup of chronic schizophrenics who did not respond (either completely or sufficiently) to other therapies.

(9). Cyproheptadine may improve akathisia in patients on antipsychotic medications.

(10).In clinical trials in which cyproheptadine was used as an adjunct to antipsychotic treatment for patients with schizophrenia, an improvement in negative symptoms was seen.

Cyproheptadine hydrochloride oral often release dosage : 

(1) allergic diseases: adult, once 2~4mg, one day 2 or 3 times.

(2) Cushing's syndrome, applicable to the treatment of cases of bilateral adrenal hyperplasia,it can inhibit the hypothalamic release of corticotropin releasing hormone (CRH) and inhibit the secretion of pituitary adrenocorticotropic hormone (ACTH), thereby lowering plasma ACTH and cortisol levels; adults start one day 8mg,which can be gradually increased to one day24mg; the usual dose is one day 12~24mg, divided doses,it needs long-term use; in the case of cortical function inadequate after total resection or subtotal bilateral adrenal, on one hand ,supple corticosteroids, on the other hand,take cyproheptadine,which can reduce the chance of occurrence of pituitary tumors.


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