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99% Procainamide Hcl

Product Name: Procainamide hydrochloride
CAS: 614-39-1
Molecular formula: C13H22ClN3O
Molecular Weight: 271.79
EINECS Number: 210-381-7
Mol File: 614-39-1.mol
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Description

Procainamide hydrochloride



Quick Detail:


Product Name: Procainamide hydrochloride

CAS: 614-39-1

Molecular formula: C13H22ClN3O

Molecular Weight: 271.79

EINECS Number: 210-381-7

Mol File: 614-39-1.mol

Chemical properties of white or light yellow crystalline powder. Melting point 165-169 ºC. Soluble in water, soluble in alcohol, slightly soluble in chloroform, very slightly soluble in ether or benzene. Odorless, hygroscopic.

Use anti-arrhythmic. Like quinidine, belong to typical membrane stabilizers. Applies to ventricular arrhythmia, atrial arrhythmia can also be used to prevent myocardial infarction and arrhythmia.


Procainamide Hydrochloride Description:


Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.


Procainamide Hydrochloride is an oral antiarrhythmic agent that has been in wide use for more than 60 years. Long term procainamide therapy is known to induce hypersensitivity reactions, autoantibody formation and a lupus-like syndrome but is a rare cause of clinically apparent acute liver injury.

 

Procainamide Hydrochloride Side effects:


There are many side effects following the induction of procainamide. These adverse effects are ventricular dysrhythmia, bradycardia, hypotension and shock. The adverse effects occur even more often if the daily doses are increased. Procainamide may also lead to drug fever and other allergic responses. There is also a chance that systemic lupus erythematosus occurs, which at the same time leads to polyarthralgia, myalgia and pleurisy. Most of these side effects may occur due to the acetylation of procainamide.


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